Platelet dysfunction in acute megakaryoblastic leukemia.

Alpha-Synuclein Expression in Acute Erythroleukaemia, Acute Megakaryoblastic Leukemia, and Normal Counterparts in Bone Marrow

Background:Alpha-synuclein is a member of synuclein family of proteins with unidentified function localized in the cytoplasm, mitochondria of neurons, and presynaptic nerve endings. Although it is found in the Lewy bodies in synucleinopathies and in Alzheimer’s disease, the protein could also be considered as a novel marker in diagnosis of dis...

Splenic rupture in acute megakaryoblastic leukemia.

A 43-year-old man with pancytopenia and circulating blast cells was found to have acute megakaryoblastic leukemia. Bone marrow biopsy disclosed reticulin fibrosis with infiltration of blast cells. Cytogenic study showed 48,XY,+15,+18. The megakaryocytic origin of blast cells was confirmed by platelet peroxidase reaction at ultrastructural level. The spleen which had not been felt on admission i...

Acute mono-megakaryoblastic leukemia associated with extreme thrombocytosis and complex karyotype abnormalities

Patient: Female, 55 Final Diagnosis: Acute leukemia Symptoms: Thrombocytosis Medication: Idarubicin HCl (Zavedos), Pfizer Clinical Procedure: - Specialty: Hematology. OBJECTIVE Adverse effect of drug therapy. BACKGROUND Thrombocytosis is usually seen in myeloproliferative disorders (MPD) and seldo...

Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase.

The c-sis gene expression in cells from a patient with acute megakaryoblastic leukemia and Down's syndrome.

The c-sis gene expression in leukemia cells from a patient with acute megakaryoblastic leukemia and Down's syndrome was studied. The leukemia blasts were identified as megakaryoblasts by the platelet peroxidase reaction and the reactivity against antiplatelet monoclonal antibodies. Leukemia cells obtained from peripheral blood or bone marrow specimens before and after initiation of chemotherapy...